InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spata24

Summary

InnateDB Protein

IDBP-137127.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spata24

Protein Name

spermatogenesis associated 24

Synonyms

2700012K08Rik; 4930583E11Rik; 5133400G04Rik; AU016220; TIPT; TIPT2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000094324

InnateDB Gene

IDBG-137123 (Spata24)

Protein Structure

UniProt Annotation

Function

Binds DNA with high affinity but does not bind to TATA boxes. Synergises with GMNN and TBP in activation of TATA box- containing promoters and with GMNN and TBPL1 in activation of the NF1 TATA-less promoter. May play a role in cytoplasm movement and removal during spermiogenesis. {ECO:0000269PubMed:18418073, ECO:0000269PubMed:19515240}.

Subcellular Localization

Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Associated with chromatin.

Disease Associations

Tissue Specificity

Testis-specific (at protein level). {ECO:0000269PubMed:18418073}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0008150	biological_process
GO:0030154	cell differentiation