Version 5.4
| Mus musculus Protein: Hist1h4a | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-137156.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Hist1h4a | ||||||||||||||||||
| Protein Name | histone cluster 1, H4a | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Protein | ENSMUSP00000100029 | ||||||||||||||||||
| InnateDB Gene | IDBG-137154 (Hist1h4a) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | ||||||||||||||||||
| Subcellular Localization | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | |||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | MGI:2448419 | ||||||||||||||||||
| InterPro |
IPR001951
Histone H4 IPR004823 TATA box binding protein associated factor (TAF) IPR007125 Histone core IPR009072 Histone-fold |
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| PFAM |
PF02969
PF00125 |
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| PRINTS |
PR00623
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| PIRSF | |||||||||||||||||||
| SMART |
SM00417
SM00803 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P62806 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-P62806 | ||||||||||||||||||
| TrEMBL | Q6B822 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 97122 | ||||||||||||||||||
| UniGene | Mm.228709 | ||||||||||||||||||
| RefSeq | NP_835499 | ||||||||||||||||||
| MGI ID | 4DOW | ||||||||||||||||||
| MGI Symbol | Hist1h4a | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS26367 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK007642 AK010085 AK011560 AK139521 AL589651 AL590388 AL590614 AY158956 AY158957 AY158958 AY158959 AY158960 AY158961 AY158962 AY158963 AY158964 AY158965 AY158966 AY158967 AY675272 BC028550 BC052219 BC057955 BC058529 BC087952 BC092144 BC111813 BC115446 BC115447 BC115448 BC115449 BC115450 BC115451 BC117010 BC117012 BC119241 BC119243 BC119611 BC119612 BC125598 BC125600 BC132186 BC132212 BC139425 BC139437 BC139809 BC152397 CH466561 CH466572 CH466620 U62672 V00753 X04652 X13235 X13236 Y12290 | ||||||||||||||||||
| GenPept | AAB04766 AAH28550 AAH57955 AAH58529 AAH87952 AAH92144 AAI11814 AAI15447 AAI15448 AAI15449 AAI15450 AAI15451 AAI15452 AAI17011 AAI17013 AAI19242 AAI19244 AAI19612 AAI19613 AAI25599 AAI25601 AAI32187 AAI32213 AAI39426 AAI39438 AAI39810 AAI52398 AAO06266 AAO06267 AAO06268 AAO06269 AAO06270 AAO06271 AAO06272 AAO06273 AAO06274 AAO06275 AAO06276 AAO06277 AAT78449 BAB25157 BAB26692 BAB27698 BAE24047 CAA24130 CAA28350 CAA31621 CAA31622 CAA72967 CAI24108 CAI24109 CAI25838 CAI25839 CAI26128 EDL10567 EDL10574 EDL32537 EDL32545 EDL32551 EDL32558 EDL32563 EDL32608 EDL32622 EDL32632 EDL38881 | ||||||||||||||||||