InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dcstamp

Summary

InnateDB Protein

IDBP-137204.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dcstamp

Protein Name

transmembrane 7 superfamily member 4

Synonyms

4833414I07Rik; DC-STAMP; FIND; mDC-STAMP; Tm7sf4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022913

InnateDB Gene

IDBG-137202 (Dcstamp)

Protein Structure

UniProt Annotation

Function

Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. {ECO:0000269PubMed:15452179, ECO:0000269PubMed:16061724, ECO:0000269PubMed:16937266, ECO:0000269PubMed:17164993, ECO:0000269PubMed:17713547, ECO:0000269PubMed:18653699, ECO:0000269PubMed:18952287, ECO:0000269PubMed:20039274, ECO:0000269PubMed:22337159}.

Subcellular Localization

Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localized to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes.

Disease Associations

Tissue Specificity

Expressed in macrophages and bone marrow dendritic cells (BM-DC). Weakly expressed in the spleen and lymph node. Highly expressed in multi-nuclear osteoclasts compared to mono-nuclear macrophages. Expressed in foreign body giant cells (FBGCs). Isoform 1 and isoform 2 are expressed in osteoclasts. {ECO:0000269PubMed:15601667, ECO:0000269PubMed:16061724, ECO:0000269PubMed:22337159}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0030308	negative regulation of cell growth
GO:0030316	osteoclast differentiation
GO:0034241	positive regulation of macrophage fusion
GO:0036006	cellular response to macrophage colony-stimulating factor stimulus
GO:0043011	myeloid dendritic cell differentiation
GO:0045657	positive regulation of monocyte differentiation
GO:0045780	positive regulation of bone resorption
GO:0061025	membrane fusion
GO:0071353	cellular response to interleukin-4
GO:0071356	cellular response to tumor necrosis factor
GO:0072675	osteoclast fusion

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0010008	endosome membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane