Mus musculus Protein: Hist1h1a
Summary
InnateDB Protein IDBP-137251.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hist1h1a
Protein Name histone cluster 1, H1a
Synonyms H1.1; H1a; H1f1; H1var3;
Species Mus musculus
Ensembl Protein ENSMUSP00000062030
InnateDB Gene IDBG-137249 (Hist1h1a)
Protein Structure
UniProt Annotation
Function Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus. Chromosome. Note=Mainly localizes in euchromatin. {ECO:0000250}.
Disease Associations
Tissue Specificity Restricted to thymus, testis and spleen. Present also in lymphocytic and neuronal cells. Increases in testis starting with a low level at day 5 and reaching high concentrations in 20-day old and adult animals. {ECO:0000269PubMed:9655912}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
Biological Process
GO:0006334 nucleosome assembly
GO:0007283 spermatogenesis
Cellular Component
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005719 nuclear euchromatin
Protein Structure and Domains
PDB ID MGI:1931523
InterPro IPR005818 Linker histone H1/H5, domain H15
IPR005819 Histone H5
PFAM PF00538
PRINTS PR00624
PIRSF
SMART SM00526
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P43275
PhosphoSite PhosphoSite-P43275
TrEMBL
UniProt Splice Variant
Entrez Gene 80838
UniGene Mm.480242
RefSeq NP_085112
MGI ID
MGI Symbol Hist1h1a
OMIM
CCDS CCDS26369
HPRD
IMGT
EMBL AL590388 AY158903 BC116820 BC116850 CH466561 L26164 Y12290
GenPept AAA37761 AAI16821 AAI16851 AAO06214 CAA72969 CAI25836 EDL32534