Version 5.4
Mus musculus Protein: Ecscr
Summary
InnateDB Protein IDBP-137292.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ecscr
Protein Name endothelial cell-specific chemotaxis regulator
Synonyms 1110006O17Rik; ARIA;
Species Mus musculus
Ensembl Protein ENSMUSP00000095223
InnateDB Gene IDBG-137290 (Ecscr)
Protein Structure
UniProt Annotation
Function Regulates endothelial chemotaxis and tube formation (By similarity). Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. {ECO:0000250, ECO:0000269PubMed:19416853}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in all tissues examined, highest expression was observed in lung and spleen endothelial cells. {ECO:0000269PubMed:19416853}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0006915 apoptotic process
GO:0006935 chemotaxis
GO:0030154 cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915795
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TZW0
PhosphoSite PhosphoSite-Q3TZW0
TrEMBL
UniProt Splice Variant
Entrez Gene 68545
UniGene Mm.329362
RefSeq NP_001028313
MGI ID
MGI Symbol Ecscr
OMIM
CCDS CCDS37763
HPRD
IMGT
EMBL AK157485 CX567856 EU025067
GenPept ABW05063 BAE34097

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca