Version 5.4
Homo sapiens Protein: COA1
Summary
InnateDB Protein IDBP-13732.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COA1
Protein Name chromosome 7 open reading frame 44
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000223336
InnateDB Gene IDBG-13730 (COA1)
Protein Structure
UniProt Annotation
Function Component of some MITRAC complex, a cytochrome c oxidase (COX) assembly intermediate complex that regulates COX assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV. {ECO:0000269PubMed:23260140}.
Subcellular Localization Mitochondrion inner membrane {ECO:0000269PubMed:22356826, ECO:0000269PubMed:23260140}; Single-pass membrane protein {ECO:0000269PubMed:22356826, ECO:0000269PubMed:23260140}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0033617 mitochondrial respiratory chain complex IV assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0031305 integral component of mitochondrial inner membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZY4
PhosphoSite PhosphoSite-Q9GZY4
TrEMBL C9JA07
UniProt Splice Variant
Entrez Gene 55744
UniGene Hs.733841
RefSeq NP_060694
HUGO HGNC:21868
OMIM 614769
CCDS CCDS5471
HPRD 07700
IMGT
EMBL AC005189 AC093645 AK001665 AK021905 AK023007 AK023053 AK293043 BC056884 CH471073
GenPept AAH56884 BAA91821 BAB13932 BAB14356 BAB14379 BAF85732 EAW94165 EAW94166 EAW94167 EAW94168 EAW94169 EAW94170

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca