Version 5.4
Mus musculus Protein: C1ql3
Summary
InnateDB Protein IDBP-137407.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1ql3
Protein Name C1q-like 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000056188
InnateDB Gene IDBG-137405 (C1ql3)
Protein Structure
UniProt Annotation
Function May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production. {ECO:0000269PubMed:21262840, ECO:0000269PubMed:21378161}.
Subcellular Localization Secreted {ECO:0000269PubMed:21378161}.
Disease Associations
Tissue Specificity Highly expressed in brain and white adipose tissue. In gonadal fat pad, expressed at lower levels in adipocytes than in the stromal vascular fraction (VSP), which contains preadipocytes, fibroblasts, endothelial cells and occasional immune cells. Expression exhibits sexually dimorphism, with higher levels in females than in males (at protein level). Tends to be up-regulated in adipose tissue from obese males, but not females. Expressed in glial cells. {ECO:0000269PubMed:21378161}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050807 regulation of synapse organization
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
Protein Structure and Domains
PDB ID MGI:2387350
InterPro IPR001073 Complement C1q protein
IPR008160 Collagen triple helix repeat
IPR008983 Tumour necrosis factor-like domain
PFAM PF00386
PF01391
PRINTS PR00007
PIRSF
SMART SM00110
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESN4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 227580
UniGene
RefSeq NP_694795
MGI ID
MGI Symbol C1ql3
OMIM
CCDS CCDS15692
HPRD
IMGT
EMBL AB044560 AB045983 AL929209 BC024634 CH466542 EU399230
GenPept AAH24634 ABY86415 BAB15806 BAB59006 CAM23728 EDL08047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca