InnateDB Protein
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IDBP-137428.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cxxc5
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Protein Name
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CXXC finger 5
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Synonyms
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4930415K17Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000054307
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InnateDB Gene
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IDBG-137426 (Cxxc5)
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Protein Structure
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Function |
May indirectly participate in activation of the NF- kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells. Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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Cellular Component |
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PDB ID |
MGI:1914643
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InterPro |
IPR002857
Zinc finger, CXXC-type
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PFAM |
PF02008
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91WA4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67393
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UniGene |
Mm.94560
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RefSeq |
NP_598448
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MGI ID |
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MGI Symbol |
Cxxc5
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OMIM |
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CCDS |
CCDS29150
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HPRD |
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IMGT |
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EMBL |
AK005364
AK015150
AK132950
BC016207
BC089314
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GenPept |
AAH16207
AAH89314
BAC25113
BAC25458
BAE21439
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