InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mrpl18

Summary

InnateDB Protein

IDBP-137437.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mrpl18

Protein Name

mitochondrial ribosomal protein L18

Synonyms

1010001C05Rik; C79879; HSPC071; MRP-L18;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078123

InnateDB Gene

IDBG-137435 (Mrpl18)

Protein Structure

UniProt Annotation

Function

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding

Biological Process

GO:0006412	translation
GO:0035928	rRNA import into mitochondrion

Cellular Component

GO:0005615	extracellular space
GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005840	ribosome

Protein Structure and Domains

PDB ID

MGI:1914931

InterPro

IPR005484 Ribosomal protein L18/L5

PFAM

PF00861

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AK003104 AK008680 AK010150 AK089039 BC011425

GenPept

AAH11425 BAB22567 BAB25828 BAB26735 BAC40714

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca