Version 5.4
Mus musculus Protein: Vpreb1
Summary
InnateDB Protein IDBP-137501.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vpreb1
Protein Name pre-B lymphocyte gene 1
Synonyms CD179a; Vpreb-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000074537
InnateDB Gene IDBG-137499 (Vpreb1)
Protein Structure
UniProt Annotation
Function Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.
Subcellular Localization
Disease Associations
Tissue Specificity Only expressed by pre-B-cells.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0002377 immunoglobulin production
GO:0006955 immune response
GO:0008361 regulation of cell size
GO:0030097 hemopoiesis
GO:0042100 B cell proliferation
GO:0048872 homeostasis of number of cells
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
Protein Structure and Domains
PDB ID MGI:98936
InterPro IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00406
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P13372
PhosphoSite PhosphoSite-
TrEMBL Q545E0
UniProt Splice Variant
Entrez Gene 22362
UniGene Mm.57574
RefSeq NP_058678
MGI ID
MGI Symbol Vpreb1
OMIM
CCDS CCDS27989
HPRD
IMGT
EMBL AK010843 AK010879 BC117051 CH466521 X05556 X05557
GenPept AAI17052 BAB27218 BAB27242 CAA29071 CAA29072 EDK97429

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca