Version 5.4
Mus musculus Protein: Pion
Summary
InnateDB Protein IDBP-137509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pion
Protein Name pigeon homolog (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000043679
InnateDB Gene IDBG-137505 (Pion)
Protein Structure
UniProt Annotation
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD. {ECO:0000269PubMed:20811458}.
Subcellular Localization Golgi apparatus, trans-Golgi network {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
Biological Process
GO:0030162 regulation of proteolysis
GO:1902004 positive regulation of beta-amyloid formation
Cellular Component
GO:0005802 trans-Golgi network
Protein Structure and Domains
PDB ID MGI:2442259
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TCV3
PhosphoSite PhosphoSite-Q3TCV3
TrEMBL
UniProt Splice Variant
Entrez Gene 212167
UniGene
RefSeq NP_780646
MGI ID
MGI Symbol Gsap
OMIM
CCDS CCDS39021
HPRD
IMGT
EMBL AK033694 AK080244 AK137494 AK170515 BC022737
GenPept AAH22737 BAC28433 BAC37858 BAE23378 BAE41852

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca