InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vdac2

Summary

InnateDB Protein

IDBP-137549.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vdac2

Protein Name

voltage-dependent anion channel 2

Synonyms

mVDAC2; mVDAC6; Vdac6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022293

InnateDB Gene

IDBG-137547 (Vdac2)

Protein Structure

UniProt Annotation

Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion outer membrane.

Disease Associations

Tissue Specificity

Highest levels of expression detected in testis, less but still abundant expression in heart, kidney, brain, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0006820	anion transport
GO:0032272	negative regulation of protein polymerization
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport
GO:2001243	negative regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome