InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cubn

Summary

InnateDB Protein

IDBP-137555.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cubn

Protein Name

cubilin (intrinsic factor-cobalamin receptor)

Synonyms

AA408369; AL022750; D2Wsu88e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000089009

InnateDB Gene

IDBG-137553 (Cubn)

Protein Structure

UniProt Annotation

Function

Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269PubMed:10766831, ECO:0000269PubMed:11278724, ECO:0000269PubMed:11856751, ECO:0000269PubMed:15342463}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney, thymus, ileum, placenta, small intestine and yolk sac. In kidney expressed on the apical brush border surface of proximal tubular cells, in particular in endosomes and recycling membranes vesicles, so-called dense apical tubules, which carry internalized receptors back to the cell surface. Expressed in fetal membranes of yolk sac, placenta of pregnant females. {ECO:0000269PubMed:10766831, ECO:0000269PubMed:11856751}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031419	cobalamin binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0008203	cholesterol metabolic process
GO:0042953	lipoprotein transport

Cellular Component

GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005903	brush border
GO:0005905	coated pit
GO:0010008	endosome membrane
GO:0016324	apical plasma membrane
GO:0030139	endocytic vesicle
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome