InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pura

Summary

InnateDB Protein

IDBP-137599.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pura

Protein Name

purine rich element binding protein A

Synonyms

CAGER-1; Pur-alpha; ssCRE-BP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000059404

InnateDB Gene

IDBG-137597 (Pura)

Protein Structure

UniProt Annotation

Function

This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the c-Myc gene. May play a role in the initiation of DNA replication and in recombination.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032422	purine-rich negative regulatory element binding
GO:0044822	poly(A) RNA binding
GO:0046332	SMAD binding

Biological Process

GO:0006268	DNA unwinding involved in DNA replication
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007093	mitotic cell cycle checkpoint
GO:0007399	nervous system development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0017148	negative regulation of translation
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated