InnateDB Protein
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IDBP-137671.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hbegf
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Protein Name
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heparin-binding EGF-like growth factor
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Synonyms
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AW047313; Dtr; Dts; Hegfl;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025363
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InnateDB Gene
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IDBG-137669 (Hbegf)
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Protein Structure
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Function |
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
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Subcellular Localization |
Heparin-binding EGF-like growth factor: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.Proheparin-binding EGF-like growth factor: Cell membrane; Single-pass type I membrane protein.
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Disease Associations |
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Tissue Specificity |
Most abundant in kidney, skeletal muscle, lung, spleen, brain and heart.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
9 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96070
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InterPro |
IPR000742
Epidermal growth factor-like domain
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PFAM |
PF00008
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
Q06186
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PhosphoSite |
PhosphoSite-Q06186
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TrEMBL |
Q5FW64
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UniProt Splice Variant |
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Entrez Gene |
15200
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UniGene |
Mm.289681
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RefSeq |
NP_034545
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MGI ID |
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MGI Symbol |
Hbegf
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OMIM |
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CCDS |
CCDS29153
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HPRD |
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IMGT |
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EMBL |
AK145548
AK160575
AK164309
BC089607
CH466557
L07264
L36024
L36025
L36026
L36027
U39189
U39190
U39191
U39192
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GenPept |
AAA37542
AAC42069
AAC52617
AAH89607
BAE26501
BAE35883
BAE37729
EDK97159
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