Mus musculus Protein: Tbxas1
Summary
InnateDB Protein IDBP-137702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbxas1
Protein Name thromboxane A synthase 1, platelet
Synonyms CYP5; CYP5A1; THAS; TS; TXAS; TXS;
Species Mus musculus
Ensembl Protein ENSMUSP00000003017
InnateDB Gene IDBG-137700 (Tbxas1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004796 thromboxane-A synthase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0030644 cellular chloride ion homeostasis
GO:0045907 positive regulation of vasoconstriction
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:98497
InterPro IPR001128 Cytochrome P450
IPR002397 Cytochrome P450, B-class
IPR002401 Cytochrome P450, E-class, group I
IPR002402 Cytochrome P450, E-class, group II
IPR002403 Cytochrome P450, E-class, group IV
IPR008072 Cytochrome P450, E-class, CYP3A
PFAM PF00067
PRINTS PR00385
PR00359
PR00463
PR00464
PR00465
PR01689
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P36423
PhosphoSite PhosphoSite-
TrEMBL Q3UTF0
UniProt Splice Variant
Entrez Gene 21391
UniGene Mm.4054
RefSeq NP_035669
MGI ID
MGI Symbol Tbxas1
OMIM
CCDS CCDS20018
HPRD
IMGT
EMBL AK139479 L18868 U41326 U41327 U41328 U41329 U41330 U41331 U41332 U41333 U41334 U41335 U41336 U41397
GenPept AAB39850 AAB87704 BAE24030