Version 5.4
Mus musculus Protein: Kcnma1
Summary
InnateDB Protein IDBP-137750.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcnma1
Protein Name potassium large conductance calcium-activated channel, subfamily M, alpha member 1
Synonyms 5730414M22Rik; BKCa; MaxiK; mSlo; mSlo1; Slo; Slo1;
Species Mus musculus
Ensembl Protein ENSMUSP00000074511
InnateDB Gene IDBG-137748 (Kcnma1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005267 potassium channel activity
GO:0015269 calcium-activated potassium channel activity
GO:0060072 large conductance calcium-activated potassium channel activity
Biological Process
GO:0001666 response to hypoxia
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0007605 sensory perception of sound
GO:0007623 circadian rhythm
GO:0007628 adult walking behavior
GO:0019228 neuronal action potential
GO:0032344 regulation of aldosterone metabolic process
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0042491 auditory receptor cell differentiation
GO:0045475 locomotor rhythm
GO:0045794 negative regulation of cell volume
GO:0046541 saliva secretion
GO:0048469 cell maturation
GO:0050885 neuromuscular process controlling balance
GO:0051260 protein homooligomerization
GO:0055085 transmembrane transport
GO:0060073 micturition
GO:0060082 eye blink reflex
GO:0060083 smooth muscle contraction involved in micturition
GO:0060087 relaxation of vascular smooth muscle
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0043195 terminal bouton
GO:0045211 postsynaptic membrane
Protein Structure and Domains
PDB ID MGI:99923
InterPro IPR003091 Potassium channel
IPR003148 Regulator of K+ conductance, N-terminal
IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain
PFAM PF02254
PF03493
PF00520
PF07885
PRINTS PR00169
PR01449
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q9EQ27
UniProt Splice Variant
Entrez Gene 16531
UniGene Mm.397259
RefSeq
MGI ID
MGI Symbol Kcnma1
OMIM
CCDS
HPRD
IMGT
EMBL AC154420 AC154433 AC154795 AF295094 CT010582
GenPept AAG40192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca