InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kcnma1

Summary

InnateDB Protein

IDBP-137754.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Kcnma1

Protein Name

potassium large conductance calcium-activated channel, subfamily M, alpha member 1

Synonyms

5730414M22Rik; BKCa; MaxiK; mSlo; mSlo1; Slo; Slo1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098393

InnateDB Gene

IDBG-137748 (Kcnma1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0015269	calcium-activated potassium channel activity
GO:0060072	large conductance calcium-activated potassium channel activity

Biological Process

GO:0001666	response to hypoxia
GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007268	synaptic transmission
GO:0007605	sensory perception of sound
GO:0007623	circadian rhythm
GO:0007628	adult walking behavior
GO:0019228	neuronal action potential
GO:0032344	regulation of aldosterone metabolic process
GO:0042311	vasodilation
GO:0042391	regulation of membrane potential
GO:0042491	auditory receptor cell differentiation
GO:0045475	locomotor rhythm
GO:0045794	negative regulation of cell volume
GO:0046541	saliva secretion
GO:0048469	cell maturation
GO:0050885	neuromuscular process controlling balance
GO:0051260	protein homooligomerization
GO:0055085	transmembrane transport
GO:0060073	micturition
GO:0060082	eye blink reflex
GO:0060083	smooth muscle contraction involved in micturition
GO:0060087	relaxation of vascular smooth muscle
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043195	terminal bouton
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:99923

InterPro

IPR003091 Potassium channel
IPR003148 Regulator of K+ conductance, N-terminal
IPR003929 Potassium channel, calcium-activated, BK, alpha subunit
IPR005821 Ion transport domain
IPR013099 Two pore domain potassium channel domain

PFAM

PF02254
PF03493
PF00520
PF07885

PRINTS

PR00169
PR01449

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite