InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eps8l1

Summary

InnateDB Protein

IDBP-137786.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eps8l1

Protein Name

EPS8-like 1

Synonyms

2310051G19Rik; 4632407K17Rik; AW060268; DRC3; EPS8R1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000083559

InnateDB Gene

IDBG-137784 (Eps8l1)

Protein Structure

UniProt Annotation

Function

Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in placenta, skin, mammary gland, bone marrow and stomach. {ECO:0000269PubMed:14565974}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0042608	T cell receptor binding
GO:0051015	actin filament binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0016601	Rac protein signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:1900029	positive regulation of ruffle assembly