InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Abra

Summary

InnateDB Protein

IDBP-137791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Abra

Protein Name

actin-binding Rho activating protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000051973

InnateDB Gene

IDBG-137789 (Abra)

Protein Structure

UniProt Annotation

Function

Acts as an activator of serum response factor (SRF)- dependent transcription possibly by inducing nuclear translocation of MKL1 or MKL2 and through a mechanism requiring Rho-actin signaling. {ECO:0000269PubMed:11983702, ECO:0000269PubMed:15798203}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to the I-band of the sarcomere and to a lesser extent to the sarcomeric structure between Z-lines. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed specifically in heart and skeletal muscle. {ECO:0000269PubMed:11983702}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003779	actin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006351	transcription, DNA-templated
GO:0035025	positive regulation of Rho protein signal transduction
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity