|
InnateDB Protein
|
IDBP-137860.7
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
Gpr31b
|
|
Protein Name
|
G protein-coupled receptor 31, D17Leh66c region
|
|
Synonyms
|
|
|
Species
|
Mus musculus
|
|
Ensembl Protein
|
ENSMUSP00000089237
|
|
InnateDB Gene
|
IDBG-137858 (Gpr31b)
|
|
Protein Structure
|
|
| Function |
High-affinity receptor for 12-(S)-hydroxy-5,8,10,14- eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B (By similarity). {ECO:0000250}.
|
| Subcellular Localization |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Disease Associations |
|
| Tissue Specificity |
|
| Comments |
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
Molecular Function |
| Accession |
GO Term |
|
GO:0004930
|
G-protein coupled receptor activity
|
|
| Biological Process |
|
GO:0007186
|
G-protein coupled receptor signaling pathway
|
|
| Cellular Component |
|
| PDB ID |
MGI:1354372
|
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like
IPR017452
GPCR, rhodopsin-like, 7TM
|
| PFAM |
PF00001
|
| PRINTS |
PR00237
|
| PIRSF |
|
| SMART |
|
| TIGRFAMs |
|
| Modification |
|
| SwissProt |
F8VQN3
|
| PhosphoSite |
PhosphoSite-
|
| TrEMBL |
|
| UniProt Splice Variant |
|
| Entrez Gene |
436440
|
| UniGene |
Mm.390936
|
| RefSeq |
NP_001013854
|
| MGI ID |
|
| MGI Symbol |
Gpr31b
|
| OMIM |
|
| CCDS |
CCDS37438
|
| HPRD |
|
| IMGT |
|
| EMBL |
AC166360
AF140708
|
| GenPept |
AAF26668
|
|
|
|
Version 5.4