InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vim

Summary

InnateDB Protein

IDBP-137866.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vim

Protein Name

vimentin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028062

InnateDB Gene

IDBG-137864 (Vim)

Protein Structure

UniProt Annotation

Function

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 189 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	47 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	189 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003725	double-stranded RNA binding
GO:0005198	structural molecule activity
GO:0005200	structural constituent of cytoskeleton
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0042802	identical protein binding
GO:0097110	scaffold protein binding

Biological Process

GO:0010628	positive regulation of gene expression
GO:0010977	negative regulation of neuron projection development
GO:0014002	astrocyte development
GO:0045103	intermediate filament-based process
GO:0045109	intermediate filament organization
GO:0060020	Bergmann glial cell differentiation
GO:0070307	lens fiber cell development

Cellular Component

GO:0005737	cytoplasm
GO:0005777	peroxisome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005882	intermediate filament
GO:0005886	plasma membrane
GO:0031252	cell leading edge
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0045098	type III intermediate filament
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome