Version 5.4
Mus musculus Protein: Defb6
Summary
InnateDB Protein IDBP-137883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb6
Protein Name defensin beta 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060836
InnateDB Gene IDBG-137881 (Defb6)
Protein Structure
UniProt Annotation
Function Has potent antibacterial activity against E.coli (ATCC 25922). {ECO:0000269PubMed:11408484}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in skeletal muscle, also expressed in esophagus, tongue, and trachea. Also expressed in lung when induced by lipopolysaccharide. {ECO:0000269PubMed:11408484}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0050829 defense response to Gram-negative bacterium
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:2151044
InterPro IPR001855 Beta defensin type
PFAM PF00711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VD6
PhosphoSite PhosphoSite-
TrEMBL Q0VDZ1
UniProt Splice Variant
Entrez Gene 116746
UniGene Mm.358822
RefSeq NP_473415
MGI ID
MGI Symbol Defb6
OMIM
CCDS CCDS40255
HPRD
IMGT
EMBL AB063109 AB063110 BC119422 BC119423 BC141871 BC141872 CH466566
GenPept AAI19423 AAI19424 AAI41872 AAI41873 BAB61108 BAB61109 EDL22233

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca