InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox2

Summary

InnateDB Protein

IDBP-137914.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox2

Protein Name

SRY-box containing gene 2

Synonyms

lcc; Sox-2; ysb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096755

InnateDB Gene

IDBG-137912 (Sox2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	35 [view]
Protein-DNA	29 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0035198	miRNA binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0001654	eye development
GO:0001708	cell fate specification
GO:0001714	endodermal cell fate specification
GO:0002052	positive regulation of neuroblast proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0007605	sensory perception of sound
GO:0009611	response to wounding
GO:0010033	response to organic substance
GO:0010468	regulation of gene expression
GO:0019827	stem cell maintenance
GO:0021879	forebrain neuron differentiation
GO:0021983	pituitary gland development
GO:0021984	adenohypophysis development
GO:0021987	cerebral cortex development
GO:0022409	positive regulation of cell-cell adhesion
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030539	male genitalia development
GO:0030858	positive regulation of epithelial cell differentiation
GO:0030900	forebrain development
GO:0030910	olfactory placode formation
GO:0032526	response to retinoic acid
GO:0035019	somatic stem cell maintenance
GO:0042246	tissue regeneration
GO:0042472	inner ear morphogenesis
GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0043586	tongue development
GO:0045165	cell fate commitment
GO:0045596	negative regulation of cell differentiation
GO:0045597	positive regulation of cell differentiation
GO:0045665	negative regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045668	negative regulation of osteoblast differentiation
GO:0045747	positive regulation of Notch signaling pathway
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046148	pigment biosynthetic process
GO:0048286	lung alveolus development
GO:0048568	embryonic organ development
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048663	neuron fate commitment
GO:0048839	inner ear development
GO:0048852	diencephalon morphogenesis
GO:0048863	stem cell differentiation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050767	regulation of neurogenesis
GO:0050910	detection of mechanical stimulus involved in sensory perception of sound
GO:0050973	detection of mechanical stimulus involved in equilibrioception
GO:0060042	retina morphogenesis in camera-type eye
GO:0060235	lens induction in camera-type eye
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0070848	response to growth factor
GO:0090090	negative regulation of canonical Wnt signaling pathway