Version 5.4
Mus musculus Protein: Angptl6
Summary
InnateDB Protein IDBP-137931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Angptl6
Protein Name angiopoietin-like 6
Synonyms 6330404E11Rik; AGF; ARP3; Arp5;
Species Mus musculus
Ensembl Protein ENSMUSP00000035784
InnateDB Gene IDBG-137929 (Angptl6)
Protein Structure
UniProt Annotation
Function May play a role in the wound healing process. May promote epidermal proliferation, remodeling and regeneration. May promote the chemotactic activity of endothelial cells and induce neovascularization. May counteract high-fat diet-induced obesity and related insulin resistance through increased energy expenditure. {ECO:0000269PubMed:12871997, ECO:0000269PubMed:14764539, ECO:0000269PubMed:15778720}.
Subcellular Localization Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Highly expressed in the liver, specifically in hepatocytes, and weakly in the heart. Expressed in hematopoietic cells, platelets and mast cells, and detected at wounded skin. {ECO:0000269PubMed:12871997}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0001525 angiogenesis
GO:0030154 cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0030141 secretory granule
Protein Structure and Domains
PDB ID MGI:1917976
InterPro IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
PFAM PF00147
PRINTS
PIRSF
SMART SM00186
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8R0Z6
PhosphoSite PhosphoSite-Q8R0Z6
TrEMBL
UniProt Splice Variant
Entrez Gene 70726
UniGene Mm.34019
RefSeq NP_660136
MGI ID
MGI Symbol Angptl6
OMIM
CCDS CCDS22886
HPRD
IMGT
EMBL AB054065 BC025904
GenPept AAH25904 BAB91249

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca