Version 5.4
Mus musculus Protein: Defb3
Summary
InnateDB Protein IDBP-137964.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Defb3
Protein Name defensin beta 3
Synonyms BD-3;
Species Mus musculus
Ensembl Protein ENSMUSP00000033852
InnateDB Gene IDBG-137962 (Defb3)
Protein Structure
UniProt Annotation
Function Antimicrobial activity against Gram-negative bacteria E.coli and P.aeruginosa. {ECO:0000269PubMed:10377137}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity Highest expression in salivary glands, epididymis, ovary and pancreas and to a lesser extent in lung, liver and brain. Low or no expression in skeletal muscle and tongue. {ECO:0000269PubMed:10377137, ECO:0000269PubMed:10922379}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006952 defense response
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
Protein Structure and Domains
PDB ID MGI:1351612
InterPro IPR001855 Beta defensin type
PFAM PF00711
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTL0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27358
UniGene Mm.103651
RefSeq NP_038784
MGI ID
MGI Symbol Defb3
OMIM
CCDS CCDS40258
HPRD
IMGT
EMBL AF092929 AF093245 BC114344 BC116176 BC116177 BC134358
GenPept AAD29572 AAD29573 AAI14345 AAI16177 AAI16178 AAI34359

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca