InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sfi1

Summary

InnateDB Protein

IDBP-138089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sfi1

Protein Name

Sfi1 homolog, spindle assembly associated (yeast)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000080066

InnateDB Gene

IDBG-138079 (Sfi1)

Protein Structure

UniProt Annotation

Function

Plays a role in the dynamic structure of centrosome- associated contractile fibers via its interaction with CETN2. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Note=Localized close to the centriole. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019902	phosphatase binding

Biological Process

GO:0010923

negative regulation of phosphatase activity

Cellular Component

GO:0005814

centriole

Protein Structure and Domains

PDB ID

MGI:1926137

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UZY0

PhosphoSite

PhosphoSite-Q3UZY0

TrEMBL

A8Y5K4

UniProt Splice Variant

Entrez Gene

78887

UniGene

Mm.485866

RefSeq

NP_084483

MGI ID

MGI Symbol

Sfi1

OMIM

CCDS

CCDS36094

HPRD

IMGT

EMBL

AK019095 AK129159 AK133558 AL671968 BC026390 BC046305 BC048950 BC106124 BX572640

GenPept

AAH26390 AAH46305 AAH48950 AAI06125 BAB31543 BAC97969 BAE21725 CAI26156 CAI35196