InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cntfr

Summary

InnateDB Protein

IDBP-138114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cntfr

Protein Name

ciliary neurotrophic factor receptor

Synonyms

Cntfralpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100026

InnateDB Gene

IDBG-138110 (Cntfr)

Protein Structure

UniProt Annotation

Function

Binds to CNTF. The alpha subunit provides the receptor specificity (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004897	ciliary neurotrophic factor receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0019955	cytokine binding

Biological Process

GO:0001967	suckling behavior
GO:0003360	brainstem development
GO:0007548	sex differentiation
GO:0008284	positive regulation of cell proliferation
GO:0043524	negative regulation of neuron apoptotic process
GO:0060538	skeletal muscle organ development
GO:0070120	ciliary neurotrophic factor-mediated signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0031225	anchored component of membrane
GO:0097059	CNTFR-CLCF1 complex

Protein Structure and Domains

PDB ID

MGI:99605

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88507