Version 5.4
Mus musculus Protein: Stam
Summary
InnateDB Protein IDBP-138132.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stam
Protein Name signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Synonyms STAM1;
Species Mus musculus
Ensembl Protein ENSMUSP00000100025
InnateDB Gene IDBG-138130 (Stam)
Protein Structure
UniProt Annotation
Function Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000305}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
Disease Associations
Tissue Specificity Ubiquitously expressed. Enriched expression in synaptic vesicles. {ECO:0000269PubMed:8780729}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006886 intracellular protein transport
Cellular Component
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID MGI:1329014
InterPro IPR001452 SH3 domain
IPR002014 VHS
IPR003903 Ubiquitin interacting motif
IPR008942 ENTH/VHS
IPR011511 Variant SH3 domain
IPR018205 VHS subgroup
PFAM PF00018
PF14604
PF00790
PF02809
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
SM00726
SM00288
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P70297
PhosphoSite PhosphoSite-P70297
TrEMBL Q3TQ49
UniProt Splice Variant
Entrez Gene 20844
UniGene Mm.474145
RefSeq NP_035614
MGI ID
MGI Symbol Stam
OMIM
CCDS CCDS15698
HPRD
IMGT
EMBL AK157767 AK163922 AK169170 BC044666 BC055326 CH466542 U43900
GenPept AAC52840 AAH44666 AAH55326 BAE34187 BAE37536 BAE40949 EDL08062

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca