InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Strn3

Summary

InnateDB Protein

IDBP-138146.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Strn3

Protein Name

striatin, calmodulin binding protein 3

Synonyms

Gs2na; SG2NA;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013130

InnateDB Gene

IDBG-138144 (Strn3)

Protein Structure

UniProt Annotation

Function

Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein.

Disease Associations

Tissue Specificity

Mainly expressed in the brain and muscles but is also detected at low levels in various tissues such as kidney, spleen and lung. {ECO:0000269PubMed:10748158}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0032403	protein complex binding
GO:0051721	protein phosphatase 2A binding
GO:0070016	armadillo repeat domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0032355	response to estradiol
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0043234	protein complex