Version 5.4
| Mus musculus Protein: Taar1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-138155.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Taar1 | ||||||||
| Protein Name | trace amine-associated receptor 1 | ||||||||
| Synonyms | taR-1; Tar1; Trar1; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000049527 | ||||||||
| InnateDB Gene | IDBG-138153 (Taar1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonine. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained speculative. Trace amines are likely to be involved in a variety of physiological functions that have yet to be fully understood. The signal transduced by this receptor is mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269PubMed:15718104}. | ||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely distributed throughout the brain. Strongly expressed in the mitral cell layer of the olfactory bulb, piriform cortex, the arcuate, motor, and mesencephalic trigeminal nuclei, lateral reticular and hypoglossal nuclei, cerebellar Purkinje cells, and ventral horn of the spinal cord. Moderately expressed in the frontal, entorhinal, and agranular cortices, the ventral pallidum, thalamus, hippocampus, several hypothalamic nuclei, ambiguus, dorsal raphe, and gigantocellular reticular nuclei. Weakly expressed in the septum, basal ganglia, amygdala, myelencephalon, and spinal cord dorsal horn. Particularly interesting is the moderate expression in several monoaminergic cell groups, namely the dorsal raphe, the locus coeruleus, and the ventral tegmental area. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:2148258 | ||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR009132 Trace amine associated receptor family IPR009133 Trace amine associated receptor 1 IPR017452 GPCR, rhodopsin-like, 7TM IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx |
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| PFAM |
PF00001
PF10320 |
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| PRINTS |
PR00237
PR01830 PR01831 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q923Y8 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 111174 | ||||||||
| UniGene | Mm.377141 | ||||||||
| RefSeq | NP_444435 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Taar1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS23735 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AF380187 BC125368 BC125370 | ||||||||
| GenPept | AAI25369 AAI25371 AAK71238 | ||||||||