InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dctn3

Summary

InnateDB Protein

IDBP-138186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dctn3

Protein Name

dynactin 3

Synonyms

p24;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030158

InnateDB Gene

IDBG-138184 (Dctn3)

Protein Structure

UniProt Annotation

Function

Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000250UniProtKB:O75935}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000910	cytokinesis
GO:0007017	microtubule-based process
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005819	spindle
GO:0005869	dynactin complex
GO:0005875	microtubule associated complex
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm