InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taar4

Summary

InnateDB Protein

IDBP-138217.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taar4

Protein Name

trace amine-associated receptor 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090330

InnateDB Gene

IDBG-138215 (Taar4)

Protein Structure

UniProt Annotation

Function

Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses. 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269PubMed:16878137, ECO:0000269PubMed:21690383, ECO:0000269PubMed:23624375}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium. {ECO:0000269PubMed:16878137, ECO:0000269PubMed:22837392}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001594	trace-amine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008227	G-protein coupled amine receptor activity
GO:1990080	2-phenylethylamine receptor activity

Biological Process

GO:0001662	behavioral fear response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007606	sensory perception of chemical stimulus
GO:0007635	chemosensory behavior

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2685072

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001520 5-Hydroxytryptamine 4 receptor
IPR009132 Trace amine associated receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01059
PR01830

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5QD15