Version 5.4
Mus musculus Protein: Macrod1
Summary
InnateDB Protein IDBP-138236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Macrod1
Protein Name MACRO domain containing 1
Synonyms AI604841; AW743046; D930010J01Rik; Lrp16;
Species Mus musculus
Ensembl Protein ENSMUSP00000039507
InnateDB Gene IDBG-138234 (Macrod1)
Protein Structure
UniProt Annotation
Function Removes ADP-ribose from glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0019213 deacetylase activity
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0042278 purine nucleoside metabolic process
GO:0051725 protein de-ADP-ribosylation
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2147583
InterPro IPR002589 Macro domain
PFAM PF01661
PRINTS
PIRSF
SMART SM00506
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922B1
PhosphoSite PhosphoSite-Q922B1
TrEMBL
UniProt Splice Variant
Entrez Gene 107227
UniGene Mm.439977
RefSeq NP_598908
MGI ID
MGI Symbol Macrod1
OMIM
CCDS CCDS50376
HPRD
IMGT
EMBL AK052998 BC008653
GenPept AAH08653 BAC35234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca