InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taar5

Summary

InnateDB Protein

IDBP-138239.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taar5

Protein Name

trace amine-associated receptor 5

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090329

InnateDB Gene

IDBG-138237 (Taar5)

Protein Structure

UniProt Annotation

Function

Olfactory receptor specific for trimethylamine, a trace amine enriched in the urine of male mice, playing a role in social behavior. Trimethylamine is present at high concentration in the urine of male mice after puberty and acts as an attractant. This receptor is probably mediated by the G(s)-class of G-proteins which activate adenylate cyclase. {ECO:0000269PubMed:16878137, ECO:0000269PubMed:23177478}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Specifically expressed in neurons of the olfactory epithelium, to discrete glomeruli predominantly localized to a confined bulb region. Present in the dorsal area of the main olfactory epithelium. {ECO:0000269PubMed:16878137, ECO:0000269PubMed:22837392}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008227	G-protein coupled amine receptor activity
GO:1990081	trimethylamine receptor activity

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007606	sensory perception of chemical stimulus
GO:0007617	mating behavior
GO:0035176	social behavior

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2685073

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR009132 Trace amine associated receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR017981 GPCR, family 2-like
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
IPR022343 GCR1-cAMP receptor

PFAM

PF00001
PF10320

PRINTS

PR00237
PR01830
PR02001

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5QD14