Version 5.4
Mus musculus Protein: Ap4s1
Summary
InnateDB Protein IDBP-138301.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ap4s1
Protein Name adaptor-related protein complex AP-4, sigma 1
Synonyms AI314282;
Species Mus musculus
Ensembl Protein ENSMUSP00000021338
InnateDB Gene IDBG-138299 (Ap4s1)
Protein Structure
UniProt Annotation
Function Subunit of novel type of clathrin- or non-clathrin- associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. {ECO:0000250}.
Subcellular Localization Golgi apparatus, trans-Golgi network {ECO:0000250}. Membrane, coated pit {ECO:0000250}. Note=Associated with the trans-Golgi network. Found in soma and dendritic shafts of neuronal cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008565 protein transporter activity
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005802 trans-Golgi network
GO:0005905 coated pit
Protein Structure and Domains
PDB ID MGI:1337065
InterPro IPR011012 Longin-like domain
IPR016635 Adaptor protein complex, sigma subunit
IPR022775 AP complex, mu/sigma subunit
PFAM PF01217
PRINTS
PIRSF PIRSF015588
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WVL1
PhosphoSite PhosphoSite-
TrEMBL Q99M60
UniProt Splice Variant
Entrez Gene 11782
UniGene Mm.386749
RefSeq NP_068356
MGI ID
MGI Symbol Ap4s1
OMIM
CCDS CCDS36441
HPRD
IMGT
EMBL AF092093 AK005283 BC001985 BC053339
GenPept AAD20447 AAH01985 AAH53339 BAB23931

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca