InnateDB Protein
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IDBP-138355.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Eny2
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Protein Name
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enhancer of yellow 2 homolog (Drosophila)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000052905
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InnateDB Gene
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IDBG-138353 (Eny2)
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Protein Structure
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Function |
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000255HAMAP- Rule:MF_03046}. Nucleus, nuclear pore complex {ECO:0000255HAMAP- Rule:MF_03046}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003713
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transcription coactivator activity
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GO:0030374
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ligand-dependent nuclear receptor transcription coactivator activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1919286
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InterPro |
IPR018783
Transcription factor, enhancer of yellow 2
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PFAM |
PF10163
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JIX0
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PhosphoSite |
PhosphoSite-Q9JIX0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
223527
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UniGene |
Mm.291828
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RefSeq |
NP_778174
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MGI ID |
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MGI Symbol |
Eny2
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OMIM |
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CCDS |
CCDS27456
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HPRD |
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IMGT |
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EMBL |
AF173297
AK032957
BC048361
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GenPept |
AAF89830
AAH48361
BAC28097
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