InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syt5

Summary

InnateDB Protein

IDBP-138360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syt5

Protein Name

synaptotagmin V

Synonyms

SytV;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070322

InnateDB Gene

IDBG-138358 (Syt5)

Protein Structure

UniProt Annotation

Function

May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)- dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface. {ECO:0000269PubMed:11751925}.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269PubMed:11751925}; Single- pass membrane protein {ECO:0000269PubMed:11751925}. Recycling endosome membrane {ECO:0000269PubMed:11751925}; Single-pass membrane protein {ECO:0000269PubMed:11751925}. Note=In mast cells, localizes to the endocytic recycling compartment.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0019905	syntaxin binding
GO:0030276	clathrin binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0017156

calcium ion-dependent exocytosis

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane