Version 5.4
Mus musculus Protein: Hic2
Summary
InnateDB Protein IDBP-138410.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hic2
Protein Name hypermethylated in cancer 2
Synonyms AA409108; HRG22; mKIAA1020;
Species Mus musculus
Ensembl Protein ENSMUSP00000087656
InnateDB Gene IDBG-138408 (Hic2)
Protein Structure
UniProt Annotation
Function Transcriptional repressor. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID MGI:1929869
InterPro IPR000210 BTB/POZ-like
IPR007087 Zinc finger, C2H2
IPR011333 BTB/POZ fold
IPR013069 BTB/POZ
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PF00651
PRINTS
PIRSF
SMART SM00225
SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLZ6
PhosphoSite PhosphoSite-Q9JLZ6
TrEMBL
UniProt Splice Variant
Entrez Gene 58180
UniGene Mm.470636
RefSeq NP_849253
MGI ID
MGI Symbol Hic2
OMIM
CCDS CCDS27999
HPRD
IMGT
EMBL AF117382 AJ868292 AK084975 AK129266 AK145386 AK156332 AK157276 BC065124
GenPept AAF28801 AAH65124 BAC39326 BAC98076 BAE26404 BAE33679 BAE34025 CAI30631

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca