InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ube2a

Summary

InnateDB Protein

IDBP-138471.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ube2a

Protein Name

ubiquitin-conjugating enzyme E2A, RAD6 homolog (S. cerevisiae)

Synonyms

HHR6A; HR6A; Mhr6a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016452

InnateDB Gene

IDBG-138469 (Ube2a)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0006281	DNA repair
GO:0008284	positive regulation of cell proliferation
GO:0009411	response to UV
GO:0033522	histone H2A ubiquitination
GO:0051865	protein autoubiquitination
GO:0060135	maternal process involved in female pregnancy
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination