InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dennd2a

Summary

InnateDB Protein

IDBP-138474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dennd2a

Protein Name

DENN/MADD domain containing 2A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045367

InnateDB Gene

IDBG-138472 (Dennd2a)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with actin filaments. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0017112	Rab guanyl-nucleotide exchange factor activity

Biological Process

GO:0015031	protein transport
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0042147	retrograde transport, endosome to Golgi