Version 5.4
Mus musculus Protein: Ppp6r1
Summary
InnateDB Protein IDBP-138518.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppp6r1
Protein Name protein phosphatase 6, regulatory subunit 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000066736
InnateDB Gene IDBG-138516 (Ppp6r1)
Protein Structure
UniProt Annotation
Function Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous with highest expression in lung, spleen and bladder. {ECO:0000269PubMed:16769727}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019903 protein phosphatase binding
Biological Process
GO:0043666 regulation of phosphoprotein phosphatase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2442163
InterPro IPR007587 SIT4 phosphatase-associated protein family
IPR016024 Armadillo-type fold
PFAM PF04499
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TSI3
PhosphoSite PhosphoSite-Q7TSI3
TrEMBL
UniProt Splice Variant
Entrez Gene 243819
UniGene Mm.410729
RefSeq NP_766482
MGI ID
MGI Symbol Ppp6r1
OMIM
CCDS CCDS39737
HPRD
IMGT
EMBL AK122450 BC053076
GenPept AAH53076 BAC65732

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca