InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ccl27a

Summary

InnateDB Protein

IDBP-138546.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ccl27a

Protein Name

chemokine (C-C motif) ligand 27A

Synonyms

ALP; AW558992; Ccl27; CTACK; CTAK; ESkine; ILC; PESKY; Scya27; Scya27a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073990

InnateDB Gene

IDBG-138544 (Ccl27a)

Protein Structure

UniProt Annotation

Function

Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. May play a role in cell migration during embryogenesis. Nuclear forms may facilitate cellular migration by inducing cytoskeletal relaxation. Binds to CCR10.

Subcellular Localization

Isoform 1: Secreted. Nucleus. Note=May also be nuclear when following receptor (CCR10)-mediated internalization.Isoform 2: Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 is predominantly expressed in placenta and weakly in skin. Isoform 2 is predominantly expressed in testes and brain, weakly in kidney and liver and even lower in heart and muscle. Low expression of both isoforms in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0006955	immune response
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus

Protein Structure and Domains

PDB ID

MGI:1343459

InterPro

IPR001811 Chemokine interleukin-8-like domain

PFAM

PF00048

PRINTS

PIRSF

SMART

SM00199

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AB013398 AF082392 AF099931 AK005398 AK005520 AL807796 BC028511 BC107226

GenPept

AAD04163 AAD41237 AAH28511 AAI07227 BAA88474 BAB24001 BAB24095

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca