Version 5.4
Mus musculus Protein: Dact2
Summary
InnateDB Protein IDBP-138566.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dact2
Protein Name dapper homolog 2, antagonist of beta-catenin (xenopus)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000051638
InnateDB Gene IDBG-138564 (Dact2)
Protein Structure
UniProt Annotation
Function Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. {ECO:0000269PubMed:17197390, ECO:0000269PubMed:18716284, ECO:0000269PubMed:20685821}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in kidney (inner medullary collecting duct). Expressed in epidermal keratinocytes and hair follicles. {ECO:0000269PubMed:18716284, ECO:0000269PubMed:20685821}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0051018 protein kinase A binding
GO:0070097 delta-catenin binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0003382 epithelial cell morphogenesis
GO:0007162 negative regulation of cell adhesion
GO:0043588 skin development
GO:0072061 inner medullary collecting duct development
GO:1900108 negative regulation of nodal signaling pathway
Cellular Component
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:1920347
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TN08
PhosphoSite PhosphoSite-Q7TN08
TrEMBL
UniProt Splice Variant
Entrez Gene 240025
UniGene Mm.79993
RefSeq NP_766414
MGI ID
MGI Symbol Dact2
OMIM
CCDS CCDS28406
HPRD
IMGT
EMBL AK041604 AY297430 BC058740
GenPept AAH58740 AAP57185 BAC31003

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca