Version 5.4
Mus musculus Protein: Qrfpr
Summary
InnateDB Protein IDBP-138575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Qrfpr
Protein Name pyroglutamylated RFamide peptide receptor
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000088768
InnateDB Gene IDBG-138573 (Qrfpr)
Protein Structure
UniProt Annotation
Function Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels (By similarity). {ECO:0000250UniProtKB:Q96P65}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Expressed widely in the brain with high levels in the cortex and hypothalamus, and moderate levels in the brain stem, caudate nucleus, midbrain hippocampus, thalamus, trigeminal ganglia and spinal cord. Particularly strong expression detected in the mitral cell layer of the olfactory bulb, accessory olfactory bulb, island of Calleja and nucleus of the solitary tract. In peripheral tissues, expressed at moderate levels in the eye, liver, kidney, pituitary gland, testis and thymus. {ECO:0000269PubMed:12714592, ECO:0000269PubMed:16648250}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2677633
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000611 Neuropeptide Y receptor family
IPR001556 Bombesin receptor
IPR005395 Neuropeptide FF receptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx
PFAM PF00001
PF10320
PRINTS PR00237
PR01012
PR00358
PR01570
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P83861
PhosphoSite PhosphoSite-
TrEMBL Q4VA00
UniProt Splice Variant
Entrez Gene 229214
UniGene Mm.330975
RefSeq NP_937835
MGI ID
MGI Symbol Qrfpr
OMIM
CCDS CCDS17311
HPRD
IMGT
EMBL AB109631 AK034431 BC096610 CH466530
GenPept AAH96610 BAC98940 BAE20492 EDL35071

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca