Version 5.4
Mus musculus Protein: Smoc2
Summary
InnateDB Protein IDBP-138591.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smoc2
Protein Name SPARC related modular calcium binding 2
Synonyms 1700056C05Rik; 5430426J21Rik; Smoc2l;
Species Mus musculus
Ensembl Protein ENSMUSP00000024660
InnateDB Gene IDBG-138589 (Smoc2)
Protein Structure
UniProt Annotation
Function Can stimulate endothelial cell proliferation, migration, as well as angiogenesis (By similarity). Promotes matrix assembly and cell adhesiveness. {ECO:0000250, ECO:0000269PubMed:18757743}.
Subcellular Localization Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269PubMed:18757743}.
Disease Associations
Tissue Specificity Strongly expressed in ovary, followed by heart, muscle, spleen, brain, thymus, lung, liver, kidney, spleen, testis, ovary and skeletal muscle. {ECO:0000269PubMed:12741954}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005539 glycosaminoglycan binding
GO:0008201 heparin binding
Biological Process
GO:0007165 signal transduction
GO:0010811 positive regulation of cell-substrate adhesion
GO:0030198 extracellular matrix organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005614 interstitial matrix
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:1929881
InterPro IPR000716 Thyroglobulin type-1
IPR002048 EF-hand domain
IPR002350 Kazal domain
IPR019577 SPARC/Testican, calcium-binding domain
PFAM PF00086
PF00036
PF13202
PF13405
PF00050
PF07648
PF10591
PRINTS
PIRSF
SMART SM00211
SM00054
SM00280
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CD91
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 64074
UniGene
RefSeq NP_071710
MGI ID
MGI Symbol Smoc2
OMIM
CCDS CCDS37442
HPRD
IMGT
EMBL AJ249901 AK006809 AK030958 BC019527
GenPept AAH19527 BAB24753 BAC27193 CAC10355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca