Mus musculus Protein: Exosc9
Summary
InnateDB Protein IDBP-138706.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exosc9
Protein Name exosome component 9
Synonyms p5; p6; PM/Scl-75; Pmscl1; RRP45;
Species Mus musculus
Ensembl Protein ENSMUSP00000029269
InnateDB Gene IDBG-138704 (Exosc9)
Protein Structure
UniProt Annotation
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.
Predicted by orthology
Total 24 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0017091 AU-rich element binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0006364 rRNA processing
GO:0030307 positive regulation of cell growth
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0071028 nuclear mRNA surveillance
GO:0071035 nuclear polyadenylation-dependent rRNA catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0045111 intermediate filament cytoskeleton
Protein Structure and Domains
PDB ID MGI:1355319
InterPro IPR001247 Exoribonuclease, phosphorolytic domain 1
IPR015847 Exoribonuclease, phosphorolytic domain 2
IPR020568 Ribosomal protein S5 domain 2-type fold
PFAM PF01138
PF03725
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JHI7
PhosphoSite PhosphoSite-Q9JHI7
TrEMBL D3YTN9
UniProt Splice Variant
Entrez Gene 50911
UniGene Mm.406108
RefSeq NP_062266
MGI ID
MGI Symbol Exosc9
OMIM
CCDS CCDS17312
HPRD
IMGT
EMBL AC117584 AF152841 AF152842 AK011636 BC005622 BC052156
GenPept AAF73218 AAF73219 AAH05622 AAH52156 BAB27749