InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agk

Summary

InnateDB Protein

IDBP-138801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agk

Protein Name

acylglycerol kinase

Synonyms

2610037M15Rik; 6720408I04Rik; AI465370; Mulk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031977

InnateDB Gene

IDBG-138799 (Agk)

Protein Structure

UniProt Annotation

Function

Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. {ECO:0000269PubMed:15252046}.

Subcellular Localization

Mitochondrion membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:15252046}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001727	lipid kinase activity
GO:0001729	ceramide kinase activity
GO:0003951	NAD+ kinase activity
GO:0004143	diacylglycerol kinase activity
GO:0005524	ATP binding
GO:0047620	acylglycerol kinase activity

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0046486	glycerolipid metabolic process
GO:0046513	ceramide biosynthetic process
GO:0046834	lipid phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0031966	mitochondrial membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:1917173

InterPro

IPR001206 Diacylglycerol kinase, catalytic domain

PFAM

PF00781

PRINTS

PIRSF

SMART

SM00046

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9ESW4

PhosphoSite

PhosphoSite-Q9ESW4

TrEMBL

UniProt Splice Variant

Entrez Gene

69923

UniGene

RefSeq

NP_076027

MGI ID

MGI Symbol

Agk

OMIM

CCDS

CCDS20027

HPRD

IMGT

EMBL

AJ401619 AK011715 AK076224 AY772469 BC019145 BC093525

GenPept

AAH19145 AAH93525 AAV38106 BAB27796 BAC36260 CAC06108