InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rtn3

Summary

InnateDB Protein

IDBP-138807.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rtn3

Protein Name

reticulon 3

Synonyms

RTN3-A1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065810

InnateDB Gene

IDBG-138805 (Rtn3)

Protein Structure

UniProt Annotation

Function

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:15350194}; Multi-pass membrane protein {ECO:0000269PubMed:15350194}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level). {ECO:0000269PubMed:15350194, ECO:0000269PubMed:15946766}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0016192	vesicle-mediated transport
GO:0071786	endoplasmic reticulum tubular network organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome