InnateDB Protein
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IDBP-138811.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rtn3
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Protein Name
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reticulon 3
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Synonyms
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RTN3-A1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000085494
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InnateDB Gene
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IDBG-138805 (Rtn3)
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Protein Structure
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Function |
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:15350194}; Multi-pass membrane protein {ECO:0000269PubMed:15350194}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1, isoform 3, isoform 4 and isoform 5 are expressed in spinal cord. Isoform 1 is present in brain, where it is expressed in the neurons of cerebral cortex, hippocampus, hypothalamus and cerebellum (at protein level). {ECO:0000269PubMed:15350194, ECO:0000269PubMed:15946766}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1339970
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InterPro |
IPR003388
Reticulon
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PFAM |
PF02453
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ES97
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PhosphoSite |
PhosphoSite-Q9ES97
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
20168
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UniGene |
Mm.414391
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RefSeq |
NP_001258416
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MGI ID |
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MGI Symbol |
Rtn3
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OMIM |
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CCDS |
CCDS70927
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HPRD |
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IMGT |
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EMBL |
AB046114
AF195940
AK032109
AK036892
AK049845
AK075883
AK088670
AK146505
AK148792
AK148947
AK165683
AY164700
AY427822
AY507126
AY507127
AY750849
BC014697
BC036717
BC079882
BK001796
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GenPept |
AAG31360
AAH14697
AAH36717
AAH79882
AAP47278
AAR08193
AAR98631
AAR98632
AAU81931
BAB62070
BAC27708
BAC29625
BAC33952
BAC36028
BAC40493
BAE27220
BAE28664
BAE28699
BAE38336
DAA01968
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